New Step by Step Map For ceesdekker
New Step by Step Map For ceesdekker
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Utilizing one-molecule optical and AFM imaging and drive-spectroscopy tactics, we seek out to unravel the mechanistic aspects of the composition and dynamics of chromosomes. Our investigation interests include:
Reconstitution of ultrawide DNA origami pores in liposomes for transmembrane transportation of macromolecules
Around the similar time, the group of Paul McEuen, who was then based for the University of California, Berkeley, confirmed related outcomes on ropes of bundled nanotubes. Based on the wrapping angle, nanotubes can come in metallic or semiconducting variants, a prediction that we and Charles Lieber’s team at Harvard University independently verified utilizing scanning tunnelling spectroscopy experiments.
I am able to barely think about how I, like a geneticist, would be capable of understand basic physics, let alone contend at the highest. How did you go about this?
2010, produced a different way (‘wedging transfer’) to govern nanostructures; first report of DNA translocation via graphene nanopores; and recognized hybrid nanopores by directed insertion of α-hemolysin into reliable-point out nanopores
Case in point (three) of bending configurations in 3D simulations of DNA rods on nanopores. A portion of the membrane is revealed in grey, the rim from the pore is highlighted in pink, and also a 3D rendering in the motion in the DNA rod is displayed.
MATLAB codes for info processing can be found at . Julia codes utilized for numerical simulation are available at .
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‘You shouldn't just contemplate the thoughts of tomorrow, but also consider the questions of the day after tomorrow’
Dekker started his investigate on solitary carbon nanotubes in 1993 when he setup a new line of exploration to review electrical transportation by single natural and organic molecules involving nanoelectrodes. In 1996 a breakthrough was realized with carbon nanotubes. This was achieved in a very collaboration With all the team of Nobel laureate Richard Smalley. STM and nanolithography tactics were utilized to show that these nanotubes are quantum wires at The one-molecule degree, with superb Bodily Attributes.
An built-in microfluidic System for quantifying drug permeation throughout biomimetic vesicle ceesdekker.net membranes
1999, very first measurement of your wavefunction of solitary molecular orbitals of carbon nanotubes; and discovery of kink heterojunctions of carbon nanotubes which gave decisive evidence for the new Luttinger description of interacting electrons in nanotubes
2005, discovery on the system of DNA uncoiling by topoisomerase enzymes; discovery of extended-range conformational alterations in Mre11/DNA repair complexes; and 1st drive measurements over a DNA molecule in a nanopore
At last, I will briefly sketch some of our Suggestions to investigate the constructing of artificial cells, specially our to start with steps to establish synthetic cell division.